In, a gifted tarot reader, is asked by his best friend, Thordao, to give a false reading to her mom as a personal favor. At her house, he runs into Thapfah, an ICU doctor and Thordao's blunt older brother, who has no patience for fortune tellers. In blurts out a chilling prediction warning that a streak of misfortune is coming for Dr. Thapfah, so severe it could even cost him his life.

Dr. Thapfah brushes it off at first. But as a series of unfortunate events hit, even his closest friend, Dr. Pokpong, and Police Inspector Ton suggest he lie low for a while. With few options left, Dr. Thapfah reluctantly agrees to retreat to Mae Hong Son with In.