Uryu Kamihate is a high school student hoping to enroll in Kyoto University's medical school. After being taken in by the chief priest at Amagami Shrine, he is told he must marry one of three maiden sisters—Yae, Yuna, or Asahi—to live at, and one day inherit, the Amagami Shrine. Kamihate will need to sweep one of the maidens off her feet in this story of romance, friendship, and fun.