The Conference USA Football Championship Game is an annual American football game that has determined the season champion of Conference USA (C-USA) since 2005.

The championship game from 2005 to 2021 showcased the C-USA East Division regular season champion against the West Division regular season champion. From the 2022 season, the game pits the number one (1) team in the season standings versus the number two (2) team. The game is typically played on the first Saturday of December. The 2018 edition of the game, sponsored by Globe Life, was played on December 1, 2018, and televised by CBSSN. Ryan LLC currently holds sponsorship rights to the game.