Modern-day doctor Qi Yue accidentally travels to the "Great Qing" while trying to save someone. She relies on her superb skills to break the shackles of the olden times to find the true meaning behind the practice of medicine. By chance, female surgeon Qi Yue finds herself in the ancient times inside the body of Qi Yueniang, the young master's wife who has been murdered. Qi Yue's arrival causes a commotion. In this new environment, she has no choice but to thrive amidst the dangers as she tries to find a way back home. When her husband Chang Yuncheng returns from guarding the borders under imperial orders, Qi Yue's already difficult situation is further tested. The two who are only married in name have to live under the same roof. Feelings of mutual distrust eventually turn into feelings of love. Qi Yue also manages to rely on her medical skills to defuse every danger. Upon seeing the unique benefits of traditional Chinese medicine, she begins studying under the guidance of masters and becomes a doctor of her generation.

Adapted from the novel Ming Men Yi Nu (名门医女) by Xi Xing (希行)