MARS RED takes place in 1923, and vampires have existed for quite a while. But now, the number of vampires is increasing and a mysterious, artificial blood source called Ascra has appeared.

The Japanese government, in turn, creates "Code Zero," an unit within the army tasked with taking down the vampiric forces. And what better way to track vampires than by using vampires?

Created by Lieutenant General Nakajima, this unit has historically been in the business of information war, but has been re-assigned to solve the vampire crisis. It's up to Code Zero and the S-class vampire Deffrot to investigate this increase and put a stop to it before society crumbles.