Begin Again tells the story of a domineering female CEO and a warm doctor who turn a fake relationship into reality due to practical reasons. Having exchanged their 'I do's', they start on a new chapter of their lives as they learn to fall in love. Lu Fangning is the general manager of Luning Group, a large corporation in the business of home furniture. Lu Fangning is a woman who has it all - talented, beautiful and rich. Nearing her thirties, Lu Fangning succumbs to family pressures and decides that she urgently needs a husband with whom she will have a child. Coincidentally, surgeon Ling Rui appears in front of her. Ling Rui is not only blessed with good looks but also has an angelic heart, which makes him the perfect candidate in the eyes of Lu Fangning. She schemes her way to his life and they finally become husband and wife. Lu Fangning eventually realizes the error in her ways and strives to be better. However, keeping a marriage is not as easy as it seems.