The show is about a trio of babies who are three characters that fight off evil monsters and aliens. Their names are Meg, Derrick and Buck and their care-giver's name is Nurse Lazlo. The show takes place in Your City, USA.

After their birth, they are brought to an orphanage. When the entire solar system aligned itself, the babies and their nurse were struck by lightning. The babies were given super strength and other powers, and Nurse Lazlo's IQ rose.

The show uses a lot of violence and toilet humor based on snot, vomit, feces, flatulence, drool, veins popping out of muscular parts, and various other bodily fluids coming from the cast.