Based on the hit investigative podcast of the same name, Up and Vanished is focused on new cases of missing individuals, as Payne Lindsey and his team of investigative podcasters search for answers to help the victims' families gain a sense of closure. Each episode featuring a different case of a missing person. New witnesses will be interviewed, and persons of interest will be confronted as Payne and his team stop at nothing to find the truth and try to unravel these mysterious disappearances.