The Game: Towards Zero tells the story of a prophet and a detective who partner up in order to solve a serial murder case.

Kim Tae Pyung is a prophet who can foresee anyone's death just by looking into their eyes. This changes when he meets Joon Young whose death he cannot see. Joon Young is a detective who works at Yongsan Police Station. She partners with a prophet to solve a mysterious murder case. Meanwhile, Goo Do Kyung is a forensic expert. He is a perfectionist who digs through every case.