Physician Dr. Stefan Frank lives with his father Dr. Eberhard Frank, his housekeeper Martha Brunnacker, the housekeeper's brother Louis Brunnacker and his receptionist Marie-Luise Flanitzer near his practice in the district of Bogenhausen in Munich. Dr. Stefan Frank is a surgeon and gynaecologist. He works together with the chief physician Dr. Ulrich Waldner and the head of the clinic Irene Kaldenbach in the Waldner-Klinik. Over all seasons and despite changing relationships he has maintained a close relationship to the practice doctor Dr. Susanne Berger who he later has a child with.