Following the events of The Young Pope, Secretary of State Voiello succeeds in having Sir John Brannox, a charming and sophisticated moderate English aristocrat, placed on the papal throne, adopting the name John Paul III. The new pope seems ideal, but he conceals secrets and has a certain fragility, and Voiello immediately understands that it will not be easy to replace the charismatic Pius XIII. Hanging between life and death, Lenny Belardo has become a Saint, with thousands now idolizing him, fueling the contrast between fundamentalisms. Meanwhile, the Church is under attack from external threats and scandals striking the symbols of Christianity and risking irreversibly devastating the hierarchies.