Miss Sherlock pays homage to the classic by Sir Arthur Conan Doyle, Sherlock Holmes, with bold interpretations of the iconic characters, Sherlock Holmes and Dr. John Watson. Miss Sherlock is set in modern day Tokyo and both lead characters are Japanese women – Dr. Wato Tachibana, a surgeon recently returned from a volunteer doctors' mission in Syria and Sara Shelly Futaba, an investigation consultant to the police department who solves bizarre and difficult cases. Throughout the series, the pair solves mystery after mystery with Miss Sherlock's extraordinary observation and reasoning skills.