On the Ykarus Biotech spacestation, the massively powerful AI Sciron, was created to save Kaladian society from the Sickness. She created a virus that protects Kaladians from disease, but robs them of all their feelings and emotions. And now Sciron is using her army of Cybers to take over.

In Last Commanders, Skye connects the players with the freedom fighters they're controlling. Not only do they talk to their avatar to guide them through the space station, the commanders hear what their character hears and see what their character sees.