In The Disappearance, Anthony's extended family is devastated by his unexplained and sudden disappearance. The series premiere opens the story the night before Anthony's disappearance and follows the family through the investigation of his sudden vanishing. As the fractured family bands together to solve the mystery that has uprooted their lives, long-held secrets are uncovered. Driven by hope and a relentless determination to do whatever necessary to uncover the mystery, the same hidden truths that threaten to shatter this family may also be the very key to reuniting them.