Alfred J. Kwak was born as the son of Johan Sebastian and Anna Kwak. Some time after his birth, Alfred loses his parents and his brothers and sisters after a car hits them. Henk the mole, a good friend of the Kwak family, raises the little orphan duck. Alfred experiences a lot of adventures.

Unlike many other cartoons targeted for children, Alfred J. Kwak features exceptionally mature and often sad themes. Amongst others it deals with different social and political issues, such as abuse of power, but also raises important values such as friendship and solidarity.