Duke's Mayo Bowl is an annual college football bowl game played at Bank of America Stadium in Charlotte, North Carolina. The game currently features a matchup between the Atlantic Coast Conference (ACC) and the Southeastern Conference (SEC). A new college football based bowl game in Charlotte, North Carolina was established in 2002 by Raycom Sports. The game was certified by the NCAA as the Queen City Bowl and was previously known as the Continental Tire Bowl (2002–2004) and the Meineke Car Care Bowl (2005–2010).

The game previously featured a matchup between the #5 selected Atlantic Coast Conference (ACC) team and the #3 selected American Athletic Conference (AAC) (originally the bowl selected a team from the Big East Conference, until the conference's breakup in 2013). In 2011, Charlotte-based department store chain Belk acquired the title sponsorship, initially for a three-year period which was to last through 2013. After the initial period, Belk announced a six-year extension of its sponsorship, through 2019. Concurrent with Belk's sponsorship extension, the bowl will feature the 2nd pooled selection from the Atlantic Coast Conference (ACC) paired against the 2nd pooled selection in the Southeastern Conference (SEC) after the College Football Playoff (CFP). In June 2020, Duke's Mayonnaise was announced as the new title sponsor for the bowl.