On March 23, 1998, 23-year-old Amy Bradley disappears without a trace from the cruise ship she and her family were vacationing on. Despite thorough searches of the ship, Amy is nowhere to be found and the cruise has already docked in their next port, Curaçao, opening the door for 2400 passengers to explore the island and allowing Amy to potentially disappear into the crowd. Hours later, Amy is still nowhere to be found and fear sets in that Amy may have fallen overboard before port. But a body is never discovered. The search for Amy expands as the FBI and local authorities launch an investigation where everyone becomes a potential suspect.

Amy Bradley Is Missing delves into this cold case decades in the making as the search for Amy continues. As the years pass by, possible sightings of Amy pop up in various locations from multiple people. Is it really her? Was this a tragic accident or a crime? - anything is possible. But for Amy's family - only one thing matters: bringing their daughter home alive.