Arab psychologist, Louie Mansur, is left to raise his two children on his own following the crushing suicide of his wife, who long-suffered a battle with depression. Louie's 13-year-old son, Amir, begins to fail his studies and is on the cusp of dropping out, whilst Louie's daughter, Nur, suffers from agonizing abandonment issues and refuses to leave Louie's side. Louie is left with no time to mourn, as his fatherly duties become all consuming.

In an unconventional turn of events, after yet another sleepless night, Louie decides to transfer his clinic hours to the wee hours of the night, accepting patients from dusk till dawn. An eclectic mix of Tel Aviv's nocturnal creatures attends his clinic, along with their compelling stories throughout the series.