Little Disasters centers on four friends who were thrown together while expectant mothers with little in common apart from their due dates. When Jess takes her baby daughter to hospital with a head injury she can't explain, close friend and on-duty A&E doctor Liz is forced to make the excruciating decision as to whether to call social services on her friend. The decision sets of a chain of events that show how a moment can fracture and nearly destroy families and friendships.