Virdee introduces Detective Harry Virdee, a Bradford cop disowned by his Sikh family for marrying Saima, who is Muslim. Harry struggles with the abandonment, constantly attempting to reunite with his family. With his personal life in chaos, he must hunt down a killer targeting the Asian community.

When the murderer kidnaps a local MP's daughter in Bradford and holds the entire city to ransom, Harry realises that he is going to need the help of his brother-in-law Riaz, a drugs kingpin who runs the largest cartel in the county. Pulled together in an alliance that could ruin them both, Harry must make a choice: save himself and his family or save his city. He will not be able to do both.