Most Talkative follows a fictionalized version of Andy Cohen growing up as a teenager in 1980s St. Louis. "He's gay, loves the Cardinals, his bar mitzvah tutor is a stoner, and his soap opera-fueled imagination makes him both the life of the party and the source of endless drama," per the official logline. "Most Talkative is a series about not fitting into any one box, and figuring out how to build your own."