Comic, podcast host and roastmaster Nikki Glaser uproots her fast-paced Hollywood lifestyle to return to her hometown of St. Louis. She embarks on a hilarious and often uncomfortable journey of self-discovery. She gets help from her parents, Julie and EJ Glaser, while leaning on her childhood friend Kerstin Robertson, platonic roommate, Andrew Collin, and even her ex-boyfriend, Chris Convy, for support. As she continues to hustle to make sure her star stays on the rise, Nikki encounters chaos and possibly love.