Vice Versa follows the adventures of Talay and Puen, who encounter bizarre scenarios. They find themselves in the bodies of strangers in a parallel universe. The only way to put a stop to this chaos is to discover the secret key that will take them back to where they came from.

Talay wakes up in the body of a man named Tess. He meets Puen, a famous actor who is now in the body of Tun after an accident. Both of them have to live their lives in a new universe that is not their home, and they might even be each other's "portkeys" which can help them to return to where they came from once they have completed what they hope to achieve. The two have Phuwadol , a male nurse who helps people from the same universe they left behind, to guide them through life in this new universe. Tun and Talay have a mission to fulfill, and they are assisted by their pals Kita, Fuse, and Friend Credits members Up and Aou. Love and friendship grow with them in the new universe. What will happen with their mission? Will they be able to get back to their home universe? Stay tuned and find out together.