The Talisman follows a 12-year old boy named Jack Sawyer who sets off on an epic road-trip quest in order to save his dying mother's life. He is in search of the Talisman, a powerful relic that can not only heal his mother but, as he learns, save the world. Sawyer's journey crisscrosses two realities: the America we know and its dangerous, fantasy-world twin, The Territories.