Pandora's Box and Ship follows the selfish and sarcastic, Lou Tucker, who is a grifter and her latest scam is stealing from packages at the Box and Ship where she works to make ends meet. But, when she opens a package that contains Pandora's actual Box, she inadvertently unleashes all of the mythological evils of the ancient world into our modern one. And, unfortunately for humanity, it's going to be up to her, a bookish Professor of Greek Mythology, and a group of unqualified misfits to put them all back in.