Three Rivers is a medical drama that goes inside the emotionally complex lives of organ donors, the recipients and the surgeons at the preeminent transplant hospital in the country, where every moment counts. However, dealing with donor families in their darkest hour and managing the fears and concerns of apprehensive recipients takes much more than just a sharp scalpel. Leading the elite team is Dr. Andy Yablonski, the highly-skilled workaholic lead organ transplant surgeon, whose good-natured personality and sarcastic wit makes him popular with his patients and colleagues. His co-workers include Dr. Miranda Foster, a surgical fellow with a rebellious streak and fiery temper who strives to live up to her deceased father's excellent surgical reputation; Dr. David Lee, a womanizing surgical resident who has broken as many hearts as he has replaced; Ryan Abbott, the inexperienced new transplant coordinator who arranges the intricately choreographed process of quickly and carefully transporting organs from donor to patient; Dr. Sophia Jordan, a brilliant surgeon at the top of her field and the head of surgery for the hospital, who has trained throughout the world, which gives her an extremely diverse point of view; Pam Acosta, Andy's no-nonsense operating assistant and best friend; and Dr. Lisa Reed, an E.R. doctor who is haunted by her past and compensates by doing everything she can to spare her patients from the pain she experienced at an early age. In this high stakes arena in which every case is a race against the clock, these tenacious surgeons and medical professionals are the last hope for their patients.