In this investigative variety show, the investigation unit composed of celebrities, who represent ordinary folks, around us will solve the cold cases using scientific method and technologies only.

Turn back time and solve a mysterious criminal case. In Sherlock's Room, criminal cases get solved by using scientific reasoning and rational deduction. Leading the group of celebrity detectives is Comedian Jung Hyung Don, the brains of the team. He is joined by Jo Woo Jong, Super Junior's Lee Teuk, Ji Min of AOA, rapper Dindin, and Inspector Kwon Il Yong.