Inspired by the books by Armistead Maupin, Tales of the City follows Mary Ann, who returns home to San Francisco and is reunited with her daughter and ex-husband Brian, twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture perfect Connecticut life created, Mary Ann returns home to her chosen family and will quickly be drawn back into the orbit of Anna Madrigal and the residents of 28 Barbary Lane.