Based on the manga xxxHOLiC by Clamp the story is about protagnist Watanuki Kimihiro whose blood attracts spirits. He is bothered by this predisposition to see the way the ghosts are affecting the people around him but he can't do anything about it..

Coming home one day, he's once again assailled by evil apparitions but his feet lead him to a strange shop called "Mise" and there he encounters Ichihara Yuko, the mysterious fascinating owner who offers to grant Watanuki's wish to remove the spirits. But the price must be of equal value, so Watanuki has to temporarily work for her in her shop that grant wishes in exchange for a "consideration". He comes across strange customers including troubled people and therworldly beings and encounters bizarre events…

Thus begins his adventures in an world full of supernatural experiences.