The Passage focuses on Project NOAH, a secret medical facility where scientists are experimenting with a dangerous virus that could lead to the cure for all disease, but also carries the potential to wipe out the human race. When a young girl is chosen to be a test subject, a federal agent is tasked with bringing her in, but ultimately, becomes her surrogate father, determined to protect her at any cost - even as Project Noah's work threatens to unleash an unimaginable apocalypse.