On Bear with Me, wildlife expert Casey Anderson lives on the edge of Yellowstone National Park in Paradise Valley, Montana, with his best friend Brutus, a grizzly bear. Having a grizzly bear as your best friend has its unique challenges, but Casey has help from his fiancée, Stephanie, and handyman Beau. These three along with Brutus help their neighbors learn how to co-exist with the wild animals that roam through their backyard. Will Casey and his team be able to keep the peace between frightened neighbors Bobbie and Lance and the mountain lions looking in their windows?