The National Lottery: Break the Safe is a BBC National Lottery game show broadcast on BBC One from July 2013. It is hosted by Nick Knowles.

Each episode has 3 couples ( friends, related or work colleagues, etc.) attempting to take as much money from the safe as possible over a number of question rounds, up to a potential maximum of £100,000. After all 3 pairs have been introduced, the host locks the safe with 6 locks. 4 of those locks will be released over the course of the game with the final 2 locks being released by the winning couple in the final round.